Quantitative NTCP pharmacophore and lack of association between DILI and NTCP Inhibition
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چکیده
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Lack of Association between ctla-4 A49G Polymorphism and Vitiligo
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چکیده ندارد.
Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake.
The Na(+) taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes. Previously, we demonstrated that nitric oxide (NO) inhibits TC uptake through S-nitrosylation of a cysteine residue. Our current aim was to determine which of the eight cysteine residues of Ntcp is responsible for NO-mediated S-nitrosylation and inhibition of TC upt...
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The sodium-taurocholate (TC) cotransporting polypeptide (NTCP) facilitates bile formation by mediating sinusoidal Na(+)-TC cotransport. During sepsis-induced cholestasis, there is a decrease in NTCP-dependent uptake of bile acids and an increase in nitric oxide (NO) levels in hepatocytes. In rat hepatocytes NO inhibits Na(+)-dependent uptake of taurocholate. The aim of this study was to extend ...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2014.09.005